HORDB

ID: hor001902
Uniprot ID: P04092
Protein name: Glicentin-related polypeptide
Gene name: gcg2
Organism: Lophius americanus (American angler) (Anglerfish)
Family: Glucagon family
Source: Animal
Expression: Produced in the A cells of the islets of Langerhans in response to a drop in blood sugar concentration.
Disease: NA
Comments: NA
Taxonomy: Lophius (genus), Lophiidae (family), Lophioidei (suborder), Lophiiformes (order), Eupercaria, Percomorphaceae, Euacanthomorphacea, Acanthomorphata, Ctenosquamata, Eurypterygia, Neoteleostei, Euteleosteomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction; GO:0050896 response to stimulus
GO CC: GO:0005576 extracellular region

Sequence: MPDQDPDRNSMLLNENSMLTEPIEPLNM
Length: 28(22-49)
Propeptide: MTSLHSLAGLLLLMIIQSSWQMPDQDPDRNSMLLNENSMLTEPIEPLNMKRHSEGTFSNDYSKYLETRRAQDFVQWLKNSKRNGLFRRHADGTYTSDVSSYLQDQAAKDFVSWLKAGRGRRE
Signal peptide: MTSLHSLAGLLLLMIIQSSWQ
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Promotes hydrolysis of glycogen and lipids, and raises the blood sugar level.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P0C0P6-F1.pdb

hor001902_AF2.pdb

hor001902_ESM.pdb

Mass:	372743	Formula:	C134H218N36O49S4
Absent amino acids:	ACFGHKVWY	Common amino acids:	LMNP
pI:	3.53	Basic residues:	1
Polar residues:	7	Hydrophobic residues:	5
Hydrophobicity:	-87.14	Boman Index:	-6898
Half-Life:	30 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	69.64
Instability Index:	6422.86	Extinction Coefficient cystines:	0
Absorbance 280nm:	0